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Research Areas
Cell Mechanics
Microphysiological Systems (MPS)
Cellular microenvironement is a dynamic space where cells interact with their surroundings, including the extracellular matrix (ECM), neighboring cells, and mechanical forces. These components directly influence cell behavior through biophysical and biochemical cues. For instance, the ECM composition and stiffness impact cell adhesion, migration, and differentiation. Our lab focuses on understanding these intricate mechanical interactions to advance regenerative medicine, cancer and drug testing. Also, the chromatin packaging holds the blueprint of life. During cellular senescence and aging, chromatin architecture undergoes significant changes. We explore how chromatin spatial organization influence gene expression, cell fate, senescence and also aim to delay aging-related effects.
We specialize in microfluidic devices, with a strong focus on developing cutting-edge organ-on-chip platforms and advanced microfluidic platforms for drug testing. We have successfully developed many organ-on-chip models such as placenta-on-chip, skin-on-chip etc. which can be used to understand intrinsic organ specific function or to model diseases but not limited to. These microfluidic devices serve as powerful alternatives to traditional animal testing and 2D cell culture methods within the pharmaceutical industry. By mimicking physiological conditions more accurately, our devices accelerate drug screening processes and enhance safety assessments.
For internship and queries mail to: iitbombay.mlab@gmail.com.
(Only the applications sent to this mail id will be considered)
Latest Research Publications
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Inhomogeneous substrate strain-driven long-range cellular patterning; A Khadpekar, N Dwivedi, P Tandaiya, A Majumder - Cell Reports Physical Science, 2025
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Competing elastic and viscous gradients determine directional cell migration; P Saez, PU Shirke, JR Seth, J Alegre-Cebollada - Mathematical Biosciences, 2025
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Directed Cell Growth of C2C12 Cells on ECM Free Bioprinted Nano/Micro Scaffolds; S Rani, RK Das, T Suryawanshi, A Jaiswal - Small, 2025
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Differential expression of oncogenic lncRNAs NEAT1 and MALAT1 in 2D monolayer vs. 3D tumoroid culture and its implications in cancer progression. Arpita Ghosh, R. Soundharya, Mohit Jolly, Abhijit Majumder, 2024, bioRxiv, doi: 10.1101/2024.10.22.619405
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Concave/Convex Curvature of Anisotropic Grooves Differentially Alters Cellular Morphology, Adhesion, and Proliferation. Yadav, S., Joshi, R. and Majumder, A., 2024. Langmuir.(2024); DOI: 10.1021/acs.langmuir.4c01896
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Spontaneous re-arrangement of evaporating suspension into mesh-patterns towards concentration gradient generation on a chip; Rakshe, M., Bachal, K., Reddy, M.P., Majumder, A. and Gandhi, P., 2024. Sādhanā, 49(1), p.69. DOI: 10.1007/s12046-023-02405-8
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Chromatin Condensation Delays Senescence in Human Mesenchymal Stem Cells by Safeguarding Nuclear Damages during In Vitro Expansion; Joshi, R., Suryawanshi, T., Mukherjee, S., Shukla, S. and Majumder, A., Journal of Tissue Engineering and Regenerative Medicine, 2024(1), p.1543849, DOI: 10.1155/2024/1543849
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Design and validation of a flowless gradient generating microfluidic device for high-throughput drug testing. Bachal, K., Yadav, S., Gandhi, P. and Majumder, A., 2023, Lab on a Chip, 23(2), pp.261-271. DOI: 10.1039/D2LC00879C
Latest News
March - 2025
- M-Lab welcomes our new post doctorate fellow, Rajat Mishra!
- Devashree presented her work at IndiaBioscience Young Investigators’ Meeting Series.
February - 2025
- Welcome Sandip Shinde! He joined M-Lab as a project staff.
- Welcome Sneha Sinha! She joined M-Lab as a project staff.
- Welcome Vidisha Panwar! She joined M-Lab as a project staff.
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